Two years after the events in Bangkok, Leslie Chow (Ken Jeong) escapes from a maximum security prison, using a riot as cover. Meanwhile in the United States, Alan Garner (Zach Galifianakis) causes a 20-car freeway pileup after he purchases a giraffe and accidentally decapitates it on a low overpass. Alan's father Sid (Jeffrey Tambor), angry with Alan for his immature antics and never owning up to his mistakes, dies of a heart attack in the middle of a lecture. After the funeral, Alan's brother-in-law Doug Billings (Justin Bartha) informs friends Phil Wenneck (Bradley Cooper) and Stu Price (Ed Helms) that Alan has been off his ADHDmedication and is out of control. The group attends an intervention in which Alan agrees to visit a rehabilitation facility in Arizona where he can seek treatment, as long as "the Wolfpack" takes him there. On the way to Arizona, Phil's minivan is rammed off the road by a rental truck and the group is taken hostage. They are later confronted by mob boss Marshall (John Goodman) and "Black Doug" (Mike Epps), his head enforcer.
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